Tumor-related imaging parameters predict response and survival after neoadjuvant chemoradiotherapy in rectal cancer

doi:10.4251/wjgo.v18.i6.117694

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 117694
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117694

Table 4 Univariate and multivariate analysis of prognostic variables for T downstaging

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95%CI	P value	HR	95%CI	P value
Age	1.011	0.975-1.047	0.553
Maximum diameter of the tumor	0.986	0.953-1.021	0.417
Length	0.990	0.970-1.011	0.333
Short diameter of the largest lymph node	0.947	0.876-1.023	0.158
Maximum diameter perpendicular to the intestinal wall on T2WI	1.034	0.980-1.099	0.252
Maximum cross-sectional area of the tumor on T2WI	1.000	0.999-1.000	0.27
Distance of the tumor from the anal verge	0.994	0.982-1.006	0.289
Carcinoembryonic antigen	0.998	0.994-1.001	0.245
Carbohydrate antigen 19-9	1.000	1.000-1.001	0.828
Body mass index	1.077	0.931-1.249	0.32
Sex	2.083	0.822-6.036	0.143
Circle	1.451	0.778-2.653	0.229
Signal	0.603	0.250-1.382	0.243
Spiculation	1.141	0.507-2.562	0.748
Node	1.019	0.430-2.565	0.968
Stratification	1.269	0.551-2.870	0.569
MRF status	4.456	1.881-11.532	0.001	3.409	1.038-12.369	0.049
Extramural vascular invasion status	1.225	0.539-2.756	0.623
ExtraMRF	1.451	0.621-3.621	0.403
Clinical T stage	4.928	2.170-12.340	0.000	1.705	0.461-6.369	0.421
Clinical N stage	0.782	0.464-1.295	0.345
Sarcopenia	1.035	0.425-2.716	0.941

HR: Hazard ratio; MRF: Mesorectal fascia; T2WI: T2-weighted imaging.

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Citation: Nie TT, Li YX, Yang X, Liu T, Niu XH, Guo XF, Liu YL. Tumor-related imaging parameters predict response and survival after neoadjuvant chemoradiotherapy in rectal cancer. World J Gastrointest Oncol 2026; 18(6): 117694
URL: https://www.wjgnet.com/1948-5204/full/v18/i6/117694.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.117694

Nie TT, Li YX, Yang X, Liu T, Niu XH, Guo XF, Liu YL. Tumor-related imaging parameters predict response and survival after neoadjuvant chemoradiotherapy in rectal cancer. World J Gastrointest Oncol 2026; 18(6): 117694 [DOI: 10.4251/wjgo.v18.i6.117694]

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