Tumor-related imaging parameters predict response and survival after neoadjuvant chemoradiotherapy in rectal cancer

Table 3 Univariate and multivariate analysis of prognostic variables for tumor regression grades

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	0.987	0.955-1.018	0.402
Maximum diameter of the tumor	1.018	0.986-1.053	0.282
Length	1.033	1.011-1.056	0.004	1.029	0.075-0.900	0.012
Short diameter of the largest lymph node	1.069	0.990-1.166	0.108
Maximum diameter perpendicular to the intestinal wall on T2WI	0.995	0.951-1.042	0.824
Maximum cross-sectional area of the tumor on T2WI	1.000	0.999-1.001	0.224
Distance of the tumor from the anal verge	1.011	0.998-1.026	0.118
Carcinoembryonic antigen	1.000	1.000-1.003	0.862
Carbohydrate antigen 19-9	1.000	0.999-1.002	0.616
Body mass index	1.044	0.919-1.188	0.511
Sex	0.676	0.316-1.458	0.314
Circle	0.877	0.485-1.537	0.652
Signal	1.524	0.743-3.131	0.249
Spiculation	0.998	0.488-2.031	0.996
Node	1.968	0.880-4.679	0.109
Stratification	0.560	0.258-1.179	0.134
MRF status	2.289	1.119-4.777	0.025	1.853	0.873-3.970	0.109
Extramural vascular invasion status	1.333	0.650-2.734	0.431
ExtraMRF	1.328	0.632-2.864	0.459
Clinical T stage	1.400	0.718-2.748	0.323
Clinical N stage	1.209	0.777-1.893	0.400
Sarcopenia	2.328	0.994-2.960	0.062

HR: Hazard ratio; MRF: Mesorectal fascia; T2WI: T2-weighted imaging.