From association to intervention: Rethinking CD24’s causal role in hepatocellular carcinogenesis

Figure 1 Cluster of differentiation 24-centered immune evasion network in hepatocellular carcinoma. Schematic illustration depicting cluster of differentiation 24 (CD24)-mediated “don’t eat me” signaling through sialic acid-binding Ig-like lectin 10 (Siglec-10) on tumor-associated macrophages (TAMs), concurrent programmed death-ligand 1 (PD-L1)/programmed death 1 (PD-1) axis suppression of T-cell cytotoxicity, and hypoxia-driven hypoxia-inducible factor-1 alpha (HIF-1α)-mediated transcriptional co-regulation. The diagram illustrates potential therapeutic intervention points including anti-CD24 monoclonal antibodies, CD24-targeting CAR-T cells, and dual checkpoint blockade strategies.