Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing

doi:10.4251/wjgo.v18.i6.117308

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 117308
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117308

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Figure 3 Overall survival by KRAS, PIK3CA, FBXW7 and TP53 status. A: Overall survival (OS) by KRAS status. Log-rank P = 0.012. Hazard ratio (HR) (mutant vs wild-type) from Cox model: 3.57 (95%CI: 1.85-6.89); B: OS by PIK3CA status. Log-rank P = 0.027. HR (mutant vs wild-type) from Cox model: 0.26 (95%CI: 0.09-0.74); C: OS by FBXW7 status. Log-rank P = 0.213. HR (mutant vs wild-type) from Cox model: 1.86 (95%CI: 0.85-4.05); D: OS by TP53 status. Log-rank P = 0.340. HR (mutant vs wild-type) from Cox model: 1.68 (95%CI: 0.87-3.25).

Citation: Zhao SQ, Luo ZF, Yang ZF, Zhang WS, Fu YM. Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing. World J Gastrointest Oncol 2026; 18(6): 117308
URL: https://www.wjgnet.com/1948-5204/full/v18/i6/117308.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.117308

Zhao SQ, Luo ZF, Yang ZF, Zhang WS, Fu YM. Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing. World J Gastrointest Oncol 2026; 18(6): 117308 [DOI: 10.4251/wjgo.v18.i6.117308]

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