Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing

Figure 2 Co-occurrence matrix of KRAS, PIK3CA, FBXW7, and TP53 genetic mutations. The heatmap illustrates the frequency of co-occurring mutations between the genes listed on the Y-axis and X-axis. The color intensity in each cell corresponds to the number of patients harboring mutations in both genes, as indicated by the scale bar (range: 0-12). Key observations include a strong co-occurrence between TP53 and FBXW7 mutations (12 patients), and between TP53 and KRAS mutations (8 patients). KRAS and PIK3CA mutations co-occurred in 4 patients. No patients had mutations in FBXW7 and KRAS, or FBXW7 and PIK3CA. Self-comparisons are zero by definition.