Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing

doi:10.4251/wjgo.v18.i6.117308

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 117308
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117308

Table 7 Cox regression analysis of KRAS, PIK3CA, FBXW7, and TP53 gene mutation status along with other high-risk factors

Variable	B	SE	Wald	df	Significance	Exp(B)	95%CI for Exp(B)
Variable	B	SE	Wald	df	Significance	Exp(B)	Lower bound	Upper bound
Gender	-1.219	0.476	6.542	1	0.011	0.296	0.116	0.752
Age	-0.432	0.43	1.007	1	0.316	0.649	0.279	1.509
KRAS mutant	1.272	0.336	14.313	1	< 0.001	3.567	1.846	6.893
PIK3CA mutant	-1.345	0.532	6.391	1	0.011	0.26	0.092	0.739
FBXW7 mutant	0.619	0.397	2.423	1	0.12	1.857	0.852	4.046
TP53 mutant	0.516	0.337	2.344	1	0.126	1.676	0.865	3.246

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Citation: Zhao SQ, Luo ZF, Yang ZF, Zhang WS, Fu YM. Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing. World J Gastrointest Oncol 2026; 18(6): 117308
URL: https://www.wjgnet.com/1948-5204/full/v18/i6/117308.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.117308

Zhao SQ, Luo ZF, Yang ZF, Zhang WS, Fu YM. Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing. World J Gastrointest Oncol 2026; 18(6): 117308 [DOI: 10.4251/wjgo.v18.i6.117308]

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