Copyright: ©Author(s) 2026.
World J Gastrointest Oncol. Jun 15, 2026; 18(6): 117308
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117308
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117308
Table 5 Association between genetic mutations, clinicopathological features and prognosis (3-year survival), n (%)
| Variable | Total (n = 87) | Death (n = 32) | Survival (n = 55) | χ² value | P value |
| Gender | 0.17 | 0.681 | |||
| Female | 24 (27.59) | 8 (25.00) | 16 (29.09) | ||
| Male | 63 (72.41) | 24 (75.00) | 39 (70.91) | ||
| Age | 3.15 | 0.076 | |||
| < 60 years | 20 (22.99) | 4 (12.50) | 16 (29.09) | ||
| ≥ 60 years | 67 (77.01) | 28 (87.50) | 39 (70.91) | ||
| KRAS mutation | 6.39 | 0.011 | |||
| Mutant | 39 (44.83) | 20 (62.50) | 19 (34.55) | ||
| Wild-type | 48 (55.17) | 12 (37.50) | 36 (65.45) | ||
| PIK3CA mutation | 0.00 | 1.000 | |||
| Mutant | 12 (13.79) | 4 (12.50) | 8 (14.55) | ||
| Wild-type | 75 (86.21) | 28 (87.50) | 47 (85.45) | ||
| FBXW7 mutation | 2.49 | 0.115 | |||
| Mutant | 24 (27.59) | 12 (37.50) | 12 (21.82) | ||
| Wild-type | 63 (72.41) | 20 (62.50) | 43(78.18) | ||
| TP53 mutation | 2.49 | 0.114 | |||
| Mutant | 56 (64.37) | 24 (75.00) | 32 (58.18) | ||
| Wild-type | 31 (35.63) | 8 (25.00) | 23 (41.82) | ||
| Diabetes | 12.32 | < 0.001 | |||
| Absent | 71 (81.61) | 20 (62.50) | 51 (92.73) | ||
| Present | 16 (18.39) | 12 (37.50) | 4 (7.27) | ||
| Hypertension | 6.39 | 0.011 | |||
| Absent | 48 (55.17) | 12 (37.50) | 36 (65.45) | ||
| Present | 39 (44.83) | 20 (62.50) | 19 (34.55) | ||
| Hyperlipidemia | 1.17 | 0.279 | |||
| Absent | 71 (81.61) | 28 (87.50) | 43 (78.18) | ||
| Present | 16 (18.39) | 4 (12.50) | 12 (21.82) | ||
| Smoking | 1.17 | 0.280 | |||
| Absent | 63 (72.41) | 21 (65.62) | 42 (76.36) | ||
| Present | 24 (27.59) | 11 (34.38) | 13 (23.64) | ||
| Alcohol use | 2.46 | 0.116 | |||
| Absent | 62 (71.26) | 26 (81.25) | 36 (65.45) | ||
| Present | 25 (28.74) | 6 (18.75) | 19 (34.55) | ||
| Tumor location | 0.94 | 0.625 | |||
| Left colon | 21 (24.14) | 8 (25.00) | 13 (23.64) | ||
| Rectum | 46 (52.87) | 15 (46.88) | 31 (56.36) | ||
| Right colon | 20 (22.99) | 9 (28.12) | 11 (20.00) | ||
| Differentiation grade | 0.80 | 0.372 | |||
| Well/moderate | 72 (82.76) | 28 (87.50) | 44 (80.00) | ||
| Poor | 15 (17.24) | 4 (12.50) | 11 (20.00) | ||
| Lymphovascular invasion | 5.60 | 0.018 | |||
| Absent | 51 (58.62) | 24 (75.00) | 27 (49.09) | ||
| Present | 36 (41.38) | 8 (25.00) | 28 (50.91) | ||
| Perineural invasion | 0.00 | 1.000 | |||
| Absent | 75 (86.21) | 28 (87.50) | 47 (85.45) | ||
| Present | 12 (13.79) | 4 (12.50) | 8 (14.55) | ||
| Preoperative pathology | 0.00 | 1.000 | |||
| Adenocarcinoma (non-special) | 82 (94.25) | 30 (93.75) | 52 (94.55) | ||
| Mucinous adenocarcinoma | 5 (5.75) | 2 (6.25) | 3 (5.45) | ||
| T stage | 1.64 | 0.201 | |||
| T1 + T2 | 5 (5.75) | 0 (0.00) | 5 (9.09) | ||
| T3 + T4 | 82 (94.25) | 32 (100.00) | 50 (90.91) | ||
| N stage | 6.37 | 0.012 | |||
| N0 | 12 (13.79) | 0 (0.00) | 12 (21.82) | ||
| N1 + N2 | 75 (86.21) | 32 (100.00) | 43 (78.18) | ||
| M stage | 1.47 | 0.225 | |||
| M0 | 71 (81.61) | 24 (75.00) | 47 (85.45) | ||
| M1 | 16 (18.39) | 8 (25.00) | 8 (14.55) | ||
| Surgical approach | 5.93 | 0.015 | |||
| Laparoscopic | 60 (68.97) | 17 (53.12) | 43 (78.18) | ||
| Open | 27 (31.03) | 15 (46.88) | 12 (21.82) | ||
| Tumor number | 3.96 | 0.047 | |||
| Solitary | 75 (86.21) | 24 (75.00) | 51 (92.73) | ||
| Multiple (≥ 2) | 12 (13.79) | 8 (25.00) | 4 (7.27) | ||
| Maximum tumor diameter | 3.02 | 0.082 | |||
| < 5 cm | 32 (36.78) | 8 (25.00) | 24 (43.64) | ||
| ≥ 5 cm | 55 (63.22) | 24 (75.00) | 31 (56.36) | ||
| Preoperative tumor markers | 4.00 | 0.046 | |||
| Absent | 65 (74.71) | 20 (62.50) | 45 (81.82) | ||
| Present | 22 (25.29) | 12 (37.50) | 10 (18.18) | ||
| Microsatellite | 0.38 | 0.535 | |||
| Microsatellite stable | 81 (93.10) | 31 (96.88) | 50 (90.91) | ||
| Microsatellite instability | 6 (6.90) | 1 (3.12) | 5 (9.09) |
- Citation: Zhao SQ, Luo ZF, Yang ZF, Zhang WS, Fu YM. Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing. World J Gastrointest Oncol 2026; 18(6): 117308
- URL: https://www.wjgnet.com/1948-5204/full/v18/i6/117308.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.117308