Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing

Table 2 Association between PIK3CA mutation status and clinicopathological features, n (%)

Clinicopathological feature	Total (n = 87)	PIK3CA mutant (n = 12)	PIK3CA wild-type (n = 75)	χ² value	P value
Tumor location				-	0.134
Left colon	21 (24.14)	6 (50.00)	15 (20.00)
Rectum	46 (52.87)	4 (33.33)	42 (56.00)
Right colon	20 (22.99)	2 (16.67)	18 (24.00)
Differentiation grade				1.67	0.197
Well/moderate	72 (82.76)	12 (100.00)	60 (80.00)
Poor	15 (17.24)	0 (0.00)	15 (20.00)
Lymphovascular invasion				0.09	0.769
Absent	51 (58.62)	8 (66.67)	43 (57.33)
Present	36 (41.38)	4 (33.33)	32 (42.67)
Perineural invasion				1.08	0.298
Absent	75 (86.21)	12 (100.00)	63 (84.00)
Present	12 (13.79)	0 (0.00)	12 (16.00)
Preoperative pathology				-	0.533
Adenocarcinoma (non-special)	82 (94.25)	11 (91.67)	71 (94.67)
Mucinous adenocarcinoma	5 (5.75)	1 (8.33)	4 (5.33)
T stage				-	1.000
T1 + T2	5 (5.75)	0 (0.00)	5 (6.67)
T3 + T4	82 (94.25)	12 (100.00)	70 (93.33)
N stage				2.77	0.096
N0	75 (86.21)	8 (66.67)	67 (89.33)
N1 + N2	12 (13.79)	4 (33.33)	8 (10.67)
M stage				1.88	0.171
M0	71 (81.61)	12 (100.00)	59 (78.67)
M1	16 (18.39)	0 (0.00)	16 (21.33)
Tumor number				2.77	0.096
Solitary	75 (86.21)	8 (66.67)	67 (89.33)
Multiple (≥ 2)	12 (13.79)	4 (33.33)	8 (10.67)
Maximum tumor diameter				6.37	0.012
< 5 cm	32 (36.78)	0 (0.00)	32 (42.67)
≥ 5 cm	55 (63.22)	12 (100.00)	43 (57.33)
Preoperative tumor markers				0.11	0.739
Normal	65 (74.71)	8 (66.67)	57 (76.00)
Elevated	22 (25.29)	4 (33.33)	18 (24.00)
Microsatellite				-	0.590
Microsatellite stable	81 (93.10)	12 (100.00)	69 (92.00)
Microsatellite instability	6 (6.90)	0 (0.00)	6 (8.00)