Letter to the Editor: Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations

doi:10.4251/wjgo.v18.i6.116624

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 116624
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.116624

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Figure 4 Yes-associated protein-mediated transcription inhibition and feedback activation of farnesoid X receptor by taurocholate. Yes-associated protein (YAP) activated by taurocholic acid recruits histone deacetylase 1 through the YAP-transcriptional enhanced associate domain complex, thereby suppressing the transcriptional activity of farnesoid X receptor. Concurrently, accumulated taurocholic acid further activates YAP through a feedback mechanism involving receptors such as sphingosine 1-phosphate receptor 2. YAP: Yes-associated protein; TEAD: Transcriptional enhanced associate domain; HDAC: Histone deacetylase; FXR: Farnesoid X receptor; TCA: Taurocholic acid; BA: Bile acid.

Citation: Wu KL, Guo D, Yang L, Li YQ, Wu YX, Zhou CF, Tang JF. Letter to the Editor: Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations. World J Gastrointest Oncol 2026; 18(6): 116624
URL: https://www.wjgnet.com/1948-5204/full/v18/i6/116624.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.116624

Wu KL, Guo D, Yang L, Li YQ, Wu YX, Zhou CF, Tang JF. Letter to the Editor: Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations. World J Gastrointest Oncol 2026; 18(6): 116624 [DOI: 10.4251/wjgo.v18.i6.116624]

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