Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching

doi:10.4251/wjgo.v18.i5.117580

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 117580
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117580

Table 2 Immunohistochemical analysis of primary gastric adenosquamous carcinoma and gastric adenocarcinoma

Characteristics	GAC (n = 468)	PGASC¹ (n = 108)	P value
P53 (-/+)	171/297	18/34	0.780
PD-L1 (< 10%/≥ 10%)	455/13	66/10	< 0.001
HER2 (-, +, ++/+++)	436/32	74/1	0.070
Ki-67 (≤ 50%/> 50%)	159/309	37/44	0.040

¹This cohort of patients with primary gastric adenosquamous carcinoma included the patients lost to follow-up.

GAC: Gastric adenocarcinoma; PGASC: Primary gastric adenosquamous carcinoma; PD-L1: Programmed cell death-ligand 1; HER2: Human epidermal growth factor receptor 2.

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Citation: Chen YW, Dong ZY, Wang XX, Cao Y, Lin JX, Chen H, Zhang HY, Xiao YB, Li GX, Li ZR, Chen L, Xia X, Zhang ZZ. Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching. World J Gastrointest Oncol 2026; 18(5): 117580
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/117580.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.117580

Chen YW, Dong ZY, Wang XX, Cao Y, Lin JX, Chen H, Zhang HY, Xiao YB, Li GX, Li ZR, Chen L, Xia X, Zhang ZZ. Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching. World J Gastrointest Oncol 2026; 18(5): 117580 [DOI: 10.4251/wjgo.v18.i5.117580]

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