Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study

doi:10.4251/wjgo.v18.i5.117512

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 117512
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117512

Table 4 Pair-wise comparisons between five groups of 3-year fibrosis-4 trajectories and risk of hepatocellular carcinoma

	HCC cases (n)	Incidence (%)	HR (95%CI)	P value
Stable 1.45-3.25	7/46	15.2	Reference	-
Stable < 1.45	0/21	0	0.12 (0.01-2.25)	0.157
Stable > 3.25	39/92	42.4	4.10 (1.66-10.13)	0.002
Improved	8/39	20.5	1.44 (0.47-4.40)	0.525
Worsened	9/45	20	1.39 (0.47-4.13)	0.55

Improved trajectory: Fibrosis-4 from > 3.25 to either 1.45-3.25 or < 1.45, or from 1.45-3.25 to < 1.45; Worsened trajectory: From < 1.45 to either 1.45-3.25 or > 3.25, or from 1.45-3.25 to > 3.25. HR: Hazard ratio; 95%CI: 95% confidence interval; HCC: Hepatocellular carcinoma.

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Citation: Li YL, Tung HD, Chuang TW, Cheng CT, Pang MG, Chen JJ, Zhong KM, Huang TY, Lee PL. Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study. World J Gastrointest Oncol 2026; 18(5): 117512
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/117512.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.117512

Li YL, Tung HD, Chuang TW, Cheng CT, Pang MG, Chen JJ, Zhong KM, Huang TY, Lee PL. Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study. World J Gastrointest Oncol 2026; 18(5): 117512 [DOI: 10.4251/wjgo.v18.i5.117512]

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