Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study

doi:10.4251/wjgo.v18.i5.117512

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 117512
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117512

Table 1 Baseline characteristics of the study cohort

Parameter	Value
Demographics
Age (years, n = 271)	66.0 (58.0-73.0)
Sex (n = 271)
Male	115 (42.4)
Female	156 (57.6)
Follow-up time (years, n = 271)	9.4 (8.7-10.1)
Virological profile
HCV viral load (IU/mL, n = 190)	941202 (64914-2861279)
HCV genotype (n = 136)
Type 1	49 (36.0)
Type 2	48 (35.3)
Type 6	23 (16.9)
Other (mixed)	16 (11.8)
Comorbidities
Hypertension (n = 271)	139 (51.3)
Diabetes mellitus (n = 271)	86 (31.7)
Dyslipidemia (n = 271)	31 (11.4)
Disease severity
Cirrhosis (n = 270)	76 (28.0)
Baseline FIB-4 index (n = 263)
< 1.45	35 (13.3)
1.45-3.25	93 (35.4)
> 3.25	135 (51.3)

Data are presented as median (interquartile range) or n (%). HCV: Hepatitis C virus; FIB-4: Fibrosis-4.

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Citation: Li YL, Tung HD, Chuang TW, Cheng CT, Pang MG, Chen JJ, Zhong KM, Huang TY, Lee PL. Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study. World J Gastrointest Oncol 2026; 18(5): 117512
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/117512.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.117512

Li YL, Tung HD, Chuang TW, Cheng CT, Pang MG, Chen JJ, Zhong KM, Huang TY, Lee PL. Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study. World J Gastrointest Oncol 2026; 18(5): 117512 [DOI: 10.4251/wjgo.v18.i5.117512]

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