Prognosis of signet-ring cell carcinoma after proximal gastrectomy was comparable to total gastrectomy but with better nutrition status

Table 4 Univariate and multivariate analyses for prognostic factors in patients with gastric cancer

Variables	Univariate analysis			Multivariate analysis
	Overall survival, (median ± SE, year)	95%CI	P value	Hazard ratio	95%CI	P value
Surgical procedure			0.059
Total gastrectomy	5.251 ± 0.320	4.424-5.677
Proximal gastrectomy	6.093 ± 0.373	5.662-7.124
Age (years old)			0.075
≤ 60	5.499 ± 0.356	4.801-6.798
< 60	5.715 ± 0.322	5.083-6.374
Tumor size			0.323
> 3 cm	5.576 ± 0.344	4.901-6.251
< 3 cm	5.593 ± 0.343	4.921-6.262
Differentiation			0.127
Poor	5.345 ± 0.244	4.868-5.822
Well-moderate	7.286 ± 0.881	5.560-9.013
Lymphatic invasion			< 0.001a
Present	3.182 ± 0.822	2.602-3.763
Absent	6.421 ± 1.315	5.338-7.392
Perineuronal invasion			0.003a
Present	3.281 ± 0.434	2.818-3.404
Absent	5.128 ± 1.121	4.277-6.778
T stage			< 0.001a			< 0.001a
T1-T2	7.291 ± 0.320	6.664-7.918		3.598	2.582-6.411
> T3	4.002 ± 0.322	3.371-4.632		1
N stage			< 0.001a
N0	6.782 ± 0.331	17.497-24.059
N1	3.941 ± 6.287	3.378-4.504
Smoke			0.117
Absent	5.135 ± 0.296	4.554-5.715
Present	6.450 ± 0.403	5.661-7.240
Drink			0.475
Absent	5.342 ± 0.296	4.761-5.923
Present	6.007 ± 0.427	5.171-6.843
Hypertension			0.052
Absent	5.983 ± 0.289	5.417-6.549
Present	4.333 ± 0.518	3.318-5.349
CAD			0.318
Absent	5.681 ± 0.272	5.148-6.214
Present	5.976 ± 0.802	4.405-7.548
Neodjuvant therapy			0.954
Absent	5.792 ± 0.300	5.203-6.380
Present	5.339 ± 0.478	4.401-6.773
Adjuvant therapy			0.003
Absent	4.622 ± 0.593	3.521-5.484
Present	5.619 ± 0.324	4.562-6.378
Relapse or metastasis			< 0.001a			0.001a
Absent	6.446 ± 0.301	5.587-7.035		2.37	1.523-3.688
Present	3.597 ± 0.377	2.858-4.336		1

^aP ≤ 0.05.

CI: Confidence interval.