Prognosis of signet-ring cell carcinoma after proximal gastrectomy was comparable to total gastrectomy but with better nutrition status

doi:10.4251/wjgo.v18.i5.117410

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 117410
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117410

Table 1 Demographic and clinicopathological characteristics of patients with upper gastric signet-ring cell carcinoma who underwent total gastrectomy or proximal gastrectomy, n (%)

Demographic and clinical characteristics		SRCC
Demographic and clinical characteristics		PG (n = 316)	TG (n = 399)	P value
Sex	Male	191 (60.4)	211 (52.9)	0.047^a
	Female	125 (39.6)	188 (47.1)
Age, mean (SD)		56.84 (11.92)	54.80 (11.77)	0.054
BMI, mean (SD)		24.65 (2.93)	23.73 (3.12)	0.273
Surgical approach	Laparotomy	181 (57.3)	215 (53.9)	< 0.001^a
	Laparoscopy	122 (38.6)	166 (41.6)
	Converted to laparotomy	13 (4.1)	18 (4.5)
Neoadjuvant therapy	No	280 (88.6)	283 (70.9)	< 0.001^a
	Yes	36 (11.4)	116 (29.1)
Size, mean (SD)		4.61 (2.85)	6.65 (3.90)	< 0.001^a
Lauren type	Intestinal	21 (6.7)	21 (5.3)	0.001^a
	Mixed	81 (25.6)	85 (21.3)
	Diffuse	214 (67.7)	293 (73.4)
Borrmann type	Superficial	204 (64.5)	112 (28.1)	< 0.001^a
	Ulcerative	112 (35.5)	287 (71.9)
Differentiation	Poorly differentiated	301 (95.3)	395 (99.0)	0.074
	Well differentiated	15 (4.7)	4 (1.0)
Vessel invasion	Negative	127 (40.2)	173 (43.6)	0.047^a
	Positive	189 (59.8)	226 (56.4)
Nerve invasion	Negative	85 (26.9)	90 (20.8)	< 0.001^a
	Positive	231 (73.1)	309 (79.2)
Pathological T-stage	T3-T4	223 (70.1)	346 (86.7)	< 0.001^a
	T1-T2	93 (29.9)	53 (13.3)
Pathological N-stage	Negative	104 (32.9)	108 (27.1)	< 0.001^a
	Positive	212 (67.1)	291 (72.9)
Pathological stage	I	88 (27.8)	66 (16.5)	< 0.001^a
	II	74 (23.4)	53 (13.3)
	III	143 (45.9)	256 (64.2)
IV	11 (2.9)	24 (6.0)

^aP ≤ 0.05.

SRCC: Signet-ring cell carcinoma; BMI: Body mass index; TG: Total gastrectomy; PG: Partial gastrectomy.

Full Size Table

Citation: Wang SD, Chang YZ, Ding SK, Bian ZM, Xie YB. Prognosis of signet-ring cell carcinoma after proximal gastrectomy was comparable to total gastrectomy but with better nutrition status. World J Gastrointest Oncol 2026; 18(5): 117410
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/117410.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.117410

Wang SD, Chang YZ, Ding SK, Bian ZM, Xie YB. Prognosis of signet-ring cell carcinoma after proximal gastrectomy was comparable to total gastrectomy but with better nutrition status. World J Gastrointest Oncol 2026; 18(5): 117410 [DOI: 10.4251/wjgo.v18.i5.117410]

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