Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling

Figure 7 Upregulated expression of metastasis-associated colon cancer 1 promoted tumor proliferation, migration, invasion and resist cell apoptosis in pancreatic cancer cells. A: Left: The mRNA level of metastasis-associated colon cancer 1 in pancreatic cancer tissues and paracancerous tissue from our local cohort. Right: Correlation expression level between expression of metastasis-associated colon cancer 1 and clinical American Joint Committee on Cancer stages or pathological grading from our local cohort; B: Proliferation of PANC-1 and ASPC after transfection was evaluated using cholecystokinin-8 assay. ^aP < 0.05, ^bP < 0.01; C: Some enriched proliferation-related pathway from gene set enrichment analyses were listed; D: The representative images of the colony formation, transwell migration and invasion in transfected PANC-1 and ASPC cells were presented; E: Apoptosis analysis of transfected pancreatic cancer cells were performed by flow cytometry; F: Some enriched related pathway from gene set enrichment analyses were listed. FDR: False discovery rate; KEGG: Kyoto Encyclopedia of Genes and Genomes; MACC1: Metastasis-associated colon cancer 1; NES: Normalized enrichment score.