Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling

Figure 4 The function mediated by metastasis-associated colon cancer 1 and its regulatory mechanism. A: Metastasis-associated colon cancer 1 (MACC1) was negative in a large number of cells, indicating that cell growth was inhibited after MACC1 knockout; B: Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed for differential-expression genes (UP); C: Enrichment differences of MACC1 in 50 HALLMARK and 85 metabolism gene sets; D: MACC1 correlation with 14 tumor-related pathway scores and 14 cancer markers, where main correlation is positive; E: The Cancer Proteome Atlas data suggested that CLAUDIN7 had a higher expression intensity in the group with high expression of MACC1 mRNA.