Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling

Figure 2 Altered genetic expression of metastasis-associated colon cancer 1. A: Metastasis-associated colon cancer 1 (MACC1) frequency of mutations in different types of tumors; B: The details of the mutation information; C: Number of cases and sites of genetic alterations of MACC1 in pancreatic cancer collected from cBioPortal; D: Histogram shows the frequency of somatic copy number alteration for MACC1 in each cancer type; E: The inter-connections between the MACC1 mRNA expression level and altered genetic expression/regulation; F: The Spearman’s correlation between somatic copy number alteration and the expression of MACC1; G: Spearman’s correlation of MACC1 between promoter methylation and transcriptional expression and (red represent positive and blue represent negative correlations); H: Heatmap showing hypermethylated (red) and hypomethylated (blue) MACC1 (Wilcoxon rank-sum test); I: Visualization of spearman correlation coefficients by radar map for MACC1 and 10 genomics features. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. MACC: Metastasis-associated colon cancer.