Impact of sintilimab with first-line therapy on tumor marker response in advanced gastric cancer

doi:10.4251/wjgo.v18.i5.117085

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 117085
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117085

Table 1 Comparison of tumor marker levels, mean ± SD

Group	Carcinoembryonic antigen (μg/mL)		CA19-9 (U/mL)			CA72-4 (U/mL)
Group	Pre-treatment	12 weeks	Pre-treatment	12 weeks	Pre-treatment	12 weeks
Control (n = 30)	8.85 ± 2.26	5.75 ± 1.70^a	74.85 ± 12.26	38.25 ± 9.10^a	12.68 ± 3.60	7.39 ± 1.65^a
Combination (n = 30)	8.90 ± 2.28	4.27 ± 1.61^a	69.80 ± 10.28	32.07 ± 10.61^a	12.20 ± 3.57	6.24 ± 1.27^a
t value	0.085	3.462	1.729	2.422	0.519	3.025
P value	0.932	0.001	0.089	0.019	0.606	0.004

^aP < 0.05 vs pre-treatment in the same group.

CA: Carbohydrate antigen.

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Citation: Quan HL, Xia L, Hu Y, Wang GY, Wang C. Impact of sintilimab with first-line therapy on tumor marker response in advanced gastric cancer. World J Gastrointest Oncol 2026; 18(5): 117085
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/117085.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.117085

Quan HL, Xia L, Hu Y, Wang GY, Wang C. Impact of sintilimab with first-line therapy on tumor marker response in advanced gastric cancer. World J Gastrointest Oncol 2026; 18(5): 117085 [DOI: 10.4251/wjgo.v18.i5.117085]

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