Copyright: ©Author(s) 2026.
World J Gastrointest Oncol. May 15, 2026; 18(5): 116882
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116882
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116882
Figure 3 A precision diagnostic and therapeutic roadmap for human epidermal growth factor receptor 2-positive gastric cancer.
This flowchart delineates the integrated clinical decision-making pathway, from initial diagnosis and molecular subtyping through the sequential selection of therapies (first- to later-line) and ongoing dynamic monitoring. NGS: Next-generation sequencing; ctDNA: Circulating tumor DNA; HER2: Human epidermal growth factor receptor 2; MET: Mesenchymal-epithelial transition factor; EGFR: Epidermal growth factor receptor; IO: Immunotherapy; ADC: Antibody-drug conjugate.
- Citation: Xu JJ, Ni CX, Wang P, Qin LD, Xu JJ. Advancing human epidermal growth factor receptor 2-positive gastric cancer therapy: Toward targeted immunotherapy and antibody-drug conjugates. World J Gastrointest Oncol 2026; 18(5): 116882
- URL: https://www.wjgnet.com/1948-5204/full/v18/i5/116882.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.116882