Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study

doi:10.4251/wjgo.v18.i5.116764

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. May 15, 2026; 18(5): 116764
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116764

Table 5 Multivariate Cox regression analysis of early recurrence-free survival

Characteristics	HR (95%CI)	P value
Age, years	0.984 (0.971-0.997)	0.016
Macrovascular invasion, positive	1.597 (1.129-2.261)	0.008
Tumor diameter, cm	1.051 (1.011-1.092)	0.011
Tumor number, multiple	1.925 (1.438-2.577)	< 0.001
MVI, positive	1.783 (1.332-2.386)	< 0.001
PNI, positive	1.512 (1.068-2.142)	0.020
Hepatic steatosis, severe	0.577 (0.339-0.983)	0.043

MVI: Microvascular invasion; PNI: Perineural invasion; HR: Hazard ratio; CI: Confidence interval.

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Citation: Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/116764.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.116764

Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764 [DOI: 10.4251/wjgo.v18.i5.116764]

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