Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study

doi:10.4251/wjgo.v18.i5.116764

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 116764
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116764

Table 4 Multivariate Cox regression analysis of overall survival

Characteristics	HR (95%CI)	P value
LY, 10⁹/L	0.725 (0.559-0.940)	0.015
Macrovascular invasion, positive	1.980 (1.417-2.766)	< 0.001
Tumor diameter, cm	1.058 (1.016-1.102)	0.006
Tumor number, multiple	1.752 (1.313-2.339)	< 0.001
MVI, positive	2.115 (1.578-2.835)	< 0.001
PNI, positive	1.732 (1.215-2.467)	0.002
Intratumoral mTLS, positive	0.676 (0.460-0.993)	0.046

LY: Lymphocyte; MVI: Microvascular invasion; PNI: Perineural invasion; mTLS: Mature tertiary lymphoid structure; HR: Hazard ratio; CI: Confidence interval.

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Citation: Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/116764.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.116764

Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764 [DOI: 10.4251/wjgo.v18.i5.116764]

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