Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study

doi:10.4251/wjgo.v18.i5.116764

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. May 15, 2026; 18(5): 116764
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116764

Table 3 Multivariate Cox regression analysis of recurrence-free survival

Characteristics	HR (95%CI)	P value
Age, years	0.982 (0.969-0.995)	0.007
Macrovascular invasion, positive	1.621 (1.156-2.271)	0.005
Tumor diameter, cm	1.048 (1.011-1.087)	0.011
Tumor number, multiple	1.937 (1.466-2.560)	< 0.001
Tumor component proportion, balanced	1.706 (1.216-2.393)	0.002
Tumor component proportion, CCA-dominant	1.524 (1.101-2.109)	0.011
MVI, positive	1.685 (1.292-2.197)	< 0.001
PNI, positive	1.445 (1.027-2.035)	0.035
Hepatic steatosis, severe	0.614 (0.383-0.984)	0.043

CCA: Cholangiocarcinoma; MVI: Microvascular invasion; PNI: Perineural invasion; HR: Hazard ratio; CI: Confidence interval.

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Citation: Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/116764.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.116764

Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; 18(5): 116764 [DOI: 10.4251/wjgo.v18.i5.116764]

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