Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities

Figure 8 Interactions of the sphingosine kinase 1/chlorogenic acid and cyclooxygenase-2/chlorogenic acid complexes. A: Chain A of sphingosine kinase 1 bound to chlorogenic acid. Inside the square, the red region indicates the binding site of chain A; B: Chain A of cyclooxygenase-2 bound to chlorogenic acid. Inside the square, the arrow indicates the heme group. The two-dimensional diagrams show the chemical bonds between receptor amino acid residues and chlorogenic acid atoms. The internal legend indicates the type of chemical bond according to the color code. Amino acid residues are represented within spheres by the three-letter code followed by the residue position in the primary sequence. L: Ligand; N: Amino-terminal; C: Carboxy-terminal.