Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities

doi:10.4251/wjgo.v18.i5.116568

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. May 15, 2026; 18(5): 116568
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116568

Table 2 Affinity energy of receptor/Ligand complexes

Receptors	Phenolic compounds
Receptors	Gallic acid (kcal/mol)	Chlorogenic acid (kcal/mol)	p-hydroxybenzoic acid (kcal/mol)
SPHK1 (PDB 3VZB)	-6.1	-8.6	-5.9
S1PR1 (PDB 7TD3)	-5.9	-8.7/-8.4	-5.7
IDO1 (PDB 5EK3)	-7.1	-8.7	-6.8
COX-2 (PDB 5F1A)	-6.3	-8.8	-6.0

SPHK1: Sphingosine kinase 1; S1PR1: Sphingosine 1-phosphate receptor 1; IDO1: Indoleamine 2,3-dioxygenase 1; COX-2: Cyclooxygenase-2.

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Citation: Da Silva PB, Lopes-Bute L, Fischer J, Parcianello AP, Pires-Duarte R, Luiz RM, Brandalize APC, Melo FF, Wendel CF, Teixeira KN, Zarpelon-Schutz AC. Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities. World J Gastrointest Oncol 2026; 18(5): 116568
URL: https://www.wjgnet.com/1948-5204/full/v18/i5/116568.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i5.116568

Da Silva PB, Lopes-Bute L, Fischer J, Parcianello AP, Pires-Duarte R, Luiz RM, Brandalize APC, Melo FF, Wendel CF, Teixeira KN, Zarpelon-Schutz AC. Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities. World J Gastrointest Oncol 2026; 18(5): 116568 [DOI: 10.4251/wjgo.v18.i5.116568]

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