Icaritin suppresses colorectal cancer invasion and metastasis through regulation of epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway

Figure 1 Icaritin inhibits growth of colorectal cancer cells. A: Cell counting kit-8 assay confirmed the suppressive effect of icaritin on HCT116 and SW620 cell proliferation, clearly showing a significant time-dependent decrease in cell growth; B: Impact of icaritin on cell proliferation and morphological alterations of human colon cancer. Morphological transformations after icaritin treatment were observed under the microscope (200 × and 400 ×). HCT116 and SW620 cells lost their fibroblast-like shape and adopted an epithelial morphology.