Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis

Figure 6 Dynamic changes in the mRNA expression of key genes in the hypoxia-inducible factor 1-alpha/BCL2/adenovirus E1B 19 kDa interacting protein 3 signaling pathway in the rat gastric mucosa. The relative mRNA expression of hypoxia-inducible factor 1-alpha, vascular endothelial growth factor, BCL2/adenovirus E1B 19 kDa interacting protein 3, Beclin1, microtubule-associated protein 1 light chain 3, sequestosome 1, cytochrome C oxidase subunit 4, hexokinase 2, and lactate dehydrogenase A was determined by quantitative real-time polymerase chain reaction. Data are presented as the mean ± SD from six independent animals per group (n = 6). ^aP < 0.05, ^bP < 0.01 vs the normal group. BNIP3: BCL2/adenovirus E1B 19 kDa interacting protein 3; COX4: Cytochrome C oxidase subunit 4; HIF-1α: Hypoxia-inducible factor 1-alpha; HK2: Hexokinase 2; LC3: Light chain 3; LDHA: Lactate dehydrogenase A; P62/SQSTM1: Sequestosome 1; VEGF: Vascular endothelial growth factor.