Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis

doi:10.4251/wjgo.v18.i4.117815

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Apr 15, 2026; 18(4): 117815
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.117815

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Figure 4 Dynamic changes in inflammation and atrophy scores of the rat gastric mucosa. A: Changes in the inflammation scores of the rat gastric mucosa; B: Changes in the atrophy scores of the rat gastric mucosa. Data are presented as the mean ± SD from six independent animals per group (n = 6). ^bP < 0.01 vs the normal group. The gastric mucosa of the normal group was bright red and glossy, plump with numerous gastric folds. Conversely, the gastric mucosa of the precancerous lesions of gastric cancer group exhibited a dark red hue, lacked luster, and reduced gastric folds.

Citation: Zhang XF, Lv GH, An SJ, Yang XR, Guo WZ, Yu CY, Zhu CH. Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis. World J Gastrointest Oncol 2026; 18(4): 117815
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/117815.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.117815

Zhang XF, Lv GH, An SJ, Yang XR, Guo WZ, Yu CY, Zhu CH. Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis. World J Gastrointest Oncol 2026; 18(4): 117815 [DOI: 10.4251/wjgo.v18.i4.117815]

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