Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis

doi:10.4251/wjgo.v18.i4.117815

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Apr 15, 2026; 18(4): 117815
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.117815

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Figure 2 Schematic of the experimental protocol and timeline. Rats in the model group were given free access to drinking water containing 150 mg/L of 1-methyl-3-nitro-1-nitrosoguanidine. Additionally, after a 12-hour fast every Wednesday and Friday, each rat in the model group was administered 2 mL of a 20% ethanol solution via oral gavage. Concurrently, rats in the normal group received an equivalent volume of normal saline. This modeling protocol was maintained for a total of 28 weeks, with sample collection at designated time points. MNNG: 1-methyl-3-nitro-1-nitrosoguanidine.

Citation: Zhang XF, Lv GH, An SJ, Yang XR, Guo WZ, Yu CY, Zhu CH. Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis. World J Gastrointest Oncol 2026; 18(4): 117815
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/117815.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.117815

Zhang XF, Lv GH, An SJ, Yang XR, Guo WZ, Yu CY, Zhu CH. Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis. World J Gastrointest Oncol 2026; 18(4): 117815 [DOI: 10.4251/wjgo.v18.i4.117815]

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