Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma

doi:10.4251/wjgo.v18.i4.116821

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Apr 15, 2026; 18(4): 116821
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116821

Table 2 Comparison of serum chitinase-3-like protein 1 levels in liver diseases patients

Group	Group serum CHI3L1 level (ng/mL)
Group	25^th percentile	50^th percentile	75^th percentile
Health control	36.79	40.99	51.47
Virus hepatitis	36.81	58.91	85.39
Non-virus hepatitis	34.50	50.89	77.34
Liver cirrhosis	61.58	100.13	161.38^a^,^b^,^c
HCC	67.38	141.07	271.77^a^,^b^,^c
HCC patients after radical resection	32.77	64.27	130.78^d^,^e
HCC recurrence	35.09	156.00	554.6^a^,^b^,^c

^aP < 0.001 vs health control.

^bP < 0.001 vs virus hepatitis.

^cP < 0.001 vs non-virus hepatitis.

^dP < 0.05 vs liver cirrhosis.

^eP < 0.05 vs hepatocellular carcinoma.

CHI3L1: Chitinase-3-like protein 1; HCC: Hepatocellular carcinoma.

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Citation: Zhang HY, Zhang RL, Jia YY, Liu Y, Zhu L, Liu F, Rao HY. Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 116821
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/116821.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.116821

Zhang HY, Zhang RL, Jia YY, Liu Y, Zhu L, Liu F, Rao HY. Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 116821 [DOI: 10.4251/wjgo.v18.i4.116821]

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