Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort

doi:10.4251/wjgo.v18.i3.116567

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 116567
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.116567

Table 7 Pairwise comparison of biomarker area under the curve values for discriminating hepatocellular carcinoma from cirrhosis

Comparison	AUC₁	AUC₂	z statistic	P value
hsa-miR-21-5p vs hsa-miR-155-5p	0.990	0.874	4.025	< 0.001
hsa-miR-21-5p vs LAIR-1 MFI	0.990	0.997	-1.218	0.223
hsa-miR-155-5p vs LAIR-1 MFI	0.874	0.997	-4.275	< 0.001

Pairwise comparisons of correlated receiver operating characteristic curves were performed using a bootstrap method (1000 replicates) to approximate the DeLong test. AUC: Area under the curve; LAIR-1: Leukocyte-associated immunoglobulin-like receptor-1; MFI: Mean fluorescence intensity.

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Citation: Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/116567.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.116567

Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567 [DOI: 10.4251/wjgo.v18.i3.116567]

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