Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort

doi:10.4251/wjgo.v18.i3.116567

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 116567
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.116567

Table 6 Receiver operating characteristic performance (hepatocellular carcinoma vs cirrhosis)

Biomarker	AUC (bootstrap 95%CI)	Optimal cutoff	Sensitivity (%)	Specificity (%)
hsa-miR-21-5p	0.990 (0.974-1.000)	> 14.0	98.6	96.7
hsa-miR-155-5p	0.874 (0.809-0.930)	> 3.8	75.7	93.3
LAIR-1⁺ T cell %	0.833 (0.767-0.895)	> 55.9	52.9	100.0
LAIR-1 MFI	0.997 (0.990-1.000)	> 29.3	100.0	98.3

Optimal cutoff values were determined by maximizing the Youden index (J). Analysis based on 70 hepatocellular carcinoma cases vs 60 cirrhosis cases. AUC: Area under the curve; CI: Confidence interval; LAIR-1: Leukocyte-associated immunoglobulin-like receptor-1; MFI: Mean fluorescence intensity.

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Citation: Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/116567.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.116567

Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567 [DOI: 10.4251/wjgo.v18.i3.116567]

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