Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort

doi:10.4251/wjgo.v18.i3.116567

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 116567
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.116567

Table 1 Baseline demographic and routine biochemical characteristics, n = 211

Parameter	HCC (n = 70)	Cirrhosis (n = 60)	Control (n = 81)	P value
Age in years	66 (6)	60 (6)	57.5 (7)	< 0.001¹
Female sex	24 (34.3)	20 (33.3)	31 (38.3)	0.350²
AFP in ng/mL	305 (720)	18 (32)	4.5 (3)	< 0.001¹
ALT in U/L	65 (38)	58 (35)	28 (10)	< 0.001¹
AST in U/L	75 (42)	62 (38)	25 (9)	< 0.001¹
Albumin in g/dL	3.1 (0.6)	3.4 (0.5)	4.2 (0.3)	< 0.001¹

¹Kruskal-Wallis test.

²χ² test.

Data are median (interquartile range) or n (%). AFP: Α-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HCC: Hepatocellular carcinoma.

Full Size Table

Citation: Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/116567.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.116567

Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567 [DOI: 10.4251/wjgo.v18.i3.116567]

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