From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance

doi:10.4251/wjgo.v18.i3.115835

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 115835
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.115835

Table 2 Regulatory mechanisms of gastric cancer stem cells genes and pathways

Gene/pathway	Role in stemness regulation
Wnt/β-catenin	Promotes self-renewal, EMT, and therapy resistance
Notch/Hedgehog/TGF-β	Maintain stemness programs, regulate cell fate and differentiation
FOXO4, TET1	Tumor suppressors; their loss enhances stemness and predicts poor prognosis
SOX9	Promotes symmetric division and expansion of GCSC pool; linked with recurrence
E2F1, PRDM1, AR, STMN1, c-Myc	Oncogenic drivers; upregulate stemness markers, proliferation, and resistance
ncRNAs (LINC00520, HCP5, circUBA2, miR-378a-3p, miR-15a-5p)	Regulate signaling pathways (Wnt, Hedgehog, Hippo) to promote or suppress stemness traits

ncRNA: Noncoding RNA; TGF: Transforming growth factor; EMT: Epithelial-mesenchymal transition; GCSC: Gastric cancer stem cell.

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Citation: Prisacariu IA, Koumarelas KE, Papadopoulos P, Schizas D, Christodoulidis G. From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance. World J Gastrointest Oncol 2026; 18(3): 115835
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/115835.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.115835

Prisacariu IA, Koumarelas KE, Papadopoulos P, Schizas D, Christodoulidis G. From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance. World J Gastrointest Oncol 2026; 18(3): 115835 [DOI: 10.4251/wjgo.v18.i3.115835]

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