From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance

doi:10.4251/wjgo.v18.i3.115835

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 115835
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.115835

Table 1 Clinical relevance of gastric cancer stem cells key markers and their significance

Gene/marker	Clinical significance
CD44	Common GCSC marker; associated with self-renewal, metastasis, and poor prognosis
CD133	Identifies chemoresistant GCSCs; linked with tumor initiation and relapse
ALDH1A1	Enzyme marker of stemness; correlates with advanced disease and survival
EpCAM	Cell adhesion molecule; supports tumor-initiating capacity
SOX2, NANOG, OCT4	Pluripotency transcription factors; sustain stem-like properties and correlate with aggressive phenotypes
LGR5	Stem cell receptor; marks progenitor-like GCSCs with poor clinical outcomes

CD: Cluster of differentiation; GCSC: Gastric cancer stem cell.

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Citation: Prisacariu IA, Koumarelas KE, Papadopoulos P, Schizas D, Christodoulidis G. From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance. World J Gastrointest Oncol 2026; 18(3): 115835
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/115835.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.115835

Prisacariu IA, Koumarelas KE, Papadopoulos P, Schizas D, Christodoulidis G. From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance. World J Gastrointest Oncol 2026; 18(3): 115835 [DOI: 10.4251/wjgo.v18.i3.115835]

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