Preoperative circulating tumor cells as a prognostic indicator in gastric cancer

Table 1 Association between circulating tumor cells status and clinicopathological characteristics in patients with gastric cancer, n (%)

Characteristics	CTCs positive	CTCs negative	P value
Number of patients	61 (53.04)	54 (46.96)
Ages (years)			0.290
≥ 65	29 (47.54)	31 (57.41)
< 65	32 (52.46)	23 (42.59)
Gender			0.464
Male	39 (63.93)	38 (70.37)
Female	22 (36.07)	16 (29.63)
BMI, mean ± SD	22.28 ± 3.78	21.27 ± 3.49	0.140
Tumor size			0.495
≥ 4 cm	41 (67.21)	33 (61.11)
< 4 cm	20 (32.79)	21 (38.89)
Differentiation of tumor
High and medium	24 (39.34)	32 (59.26)	0.033
Low and none	37 (60.66)	22 (40.74)
Tumor location			0.301
Non-antrum	28 (45.90)	30 (55.56)
Antrum	33 (54.10)	24 (44.44)
pT			0.685
T1 + 2	16 (26.23)	16 (29.63)
T3 + 4	45 (73.77)	38 (70.37)
pN			0.038
No	12 (19.67)	20 (37.04)
Yes	49 (80.33)	34 (63.96)
pM			0.033
M0	51 (83.61)	52 (96.30)
M1	10 (16.39)	2 (3.70)
pTNM			0.040
I + II	18 (29.51)	26 (48.14)
III + IV	43 (70.49)	28 (51.85)
Perineural invasion			0.424
No	12 (19.67)	14 (25.93)
Yes	49 (80.32)	40 (70.07)
Lymphovascular invasion			0.420
No	13 (21.31)	15 (27.78)
Yes	48 (76.69)	39 (72.22)
Coagulation parameters, mean ± SD
PT	12.14 ± 1.01	12.56 ± 2.57	0.245
APTT	31.05 ± 7.21	34.47 ± 5.68	0.006
TT	14.75 ± 1.61	15.38 ± 1.34	0.027
FIB	3.67 ± 0.91	3.59 ± 0.68	0.642
D-dimer	443.56 ± 1190.99	112.16 ± 98.18	0.034
PLT	276.09 ± 83.54	232.25 ± 55.92	0.001

CTCs: Circulating tumor cells; BMI: Body mass index; PT: Prothrombin time; APTT: Activated partial thromboplastin time; TT: Thrombin time; FIB: Fibrinogen; PLT: Platelet; pTNM: Pathologic tumour, node, and metastasis.