Goosecoid drives colorectal cancer progression by inducing epithelial-mesenchymal transition

doi:10.4251/wjgo.v18.i3.115028

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Mar 15, 2026; 18(3): 115028
Published online Mar 15, 2026. doi: 10.4251/wjgo.v18.i3.115028

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Figure 5 Goosecoid may promote the onset and progression of colorectal cancer via the Wnt/β-catenin signaling pathway. A: Wnt/β-catenin signaling target gene expression was reduced in goosecoid (GSC)-knockdown cells; B: Wnt/β-catenin signaling target gene expression was elevated in GSC-overexpressing cells; C: Lithium chloride treatment restored the expression of Wnt/β-catenin target genes in GSC-knockdown cells. Data are presented as the mean ± SD of three independent experiments. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. GSC: Goosecoid.

Citation: Li BC, Wang BZ, Han L, Zhang ZW, Wang Y, Zhang YJ, Zhang JN. Goosecoid drives colorectal cancer progression by inducing epithelial-mesenchymal transition. World J Gastrointest Oncol 2026; 18(3): 115028
URL: https://www.wjgnet.com/1948-5204/full/v18/i3/115028.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i3.115028

Li BC, Wang BZ, Han L, Zhang ZW, Wang Y, Zhang YJ, Zhang JN. Goosecoid drives colorectal cancer progression by inducing epithelial-mesenchymal transition. World J Gastrointest Oncol 2026; 18(3): 115028 [DOI: 10.4251/wjgo.v18.i3.115028]

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