MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway

Figure 10  Changes in xenograft tumors in nude mice after overexpression or inhibition of miR-27b-5p. A: Tumor images of subcutaneous tumors in nude mice constructed by lentivirus transfection overexpression of miR-27b-5p in AGS cells (LV-miR-27b-5p and negative control group LV-negative control), and knockdown of miR-27b-5p (anti-LV-miR-27b-5p and negative control group anti-LV-negative control); B and C: Changes in subcutaneous tumor weight and volume of nude mice injected with AGS cells overexpression or inhibition of miR-27b-5p; D: Growth curve of subcutaneous tumors in nude mice that have been injected with AGS cells exhibiting either overexpression or inhibition of miR-27b-5p; E: Expression status of cAMP response element-binding protein zinc finger/signal transducer and activator of transcription 3 associated proteins in xenograft tumors of nude mice following overexpression or inhibition of miR-27b-5p. ^bP < 0.01. NC: Negative control; STAT3: Signal transducer and activator of transcription 3; CREBZF: cAMP response element-binding protein zinc finger; Bcl-2: B-cell lymphoma 2; Bax: Bcl-2-associated X protein; p-STAT3: Phosphorylated signal transducer and activator of transcription 3.