MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway

Figure 4 Influence of miR-27b-5p on the mRNA and protein expression of cAMP response element-binding protein zinc finger. A: Dual-luciferase reporter experiment demonstrated that miR-27b-5p targeted cAMP response element-binding protein zinc finger (CREBZF); B and C: Relative mRNA and protein expression of CREBZF in 15 gastric cancer and adjacent noncancerous tissue; D: Overexpression or inhibition of miR-27b-5p affected mRNA and protein expression of CREBZF in AGS cell line; E: Overexpression or inhibition of miR-27b-5p affected mRNA and protein expression of CREBZF in NCI-N87 cell line. ^aP < 0.05, and ^bP < 0.01. MUT: Mutant-type; WT: Wild-type; NC: Negative control; CREBZF: cAMP response element-binding protein zinc finger.