Clinical characteristics of programmed death-1 inhibitors for older patients with advanced pancreatic cancer

Table 3 Univariate and multivariate analyses of overall survival among patients with advanced pancreatic carcinoma

Clinical variable	n	OS univariate			OS multivariate
		Median (months)	95%CI	P value	HR	95%CI	P value
Age, < 75 years	70	6.8	4.00-9.60	0.088
Sex, male	60	6.8	5.85-7.76	0.190
ECOG PS				< 0.001	0.229	0.115-0.454	< 0.001
0-1	65	11.0	7.43-14.57
2	34	2.6	1.31-3.89
HBV infection				0.241
Positive	9	9.0	2.23-15.77
Negative	90	7.5	5.67-9.33
Primary tumor location				0.018	1.776	0.988-3.191	0.055
Pancreatic head	46	6.8	4.03-9.57
Body & tail	53	8.6	3.89-13.31
Number of prior systemic therapy lines				0.148
0	70	8.6	6.02-11.18
1	29	6.0	3.68-8.32
Baseline serum CA199 levels (U/mL)				0.003	0.990	0.563-1.741	0.972
< 173.55	43	10.6	8.70-12.50
≥ 173.55	56	5.8	4.05-7.55
SII				0.001	0.502	0.237-1.063	0.072
< 531.575	49	10.4	8.69-12.11
≥ 531.575	50	4.5	2.56-6.45
NLR				< 0.001	0.548	0.238-1.264	0.158
< 2.1	38	10.6	5.14-16.07
≥ 2.1	61	5.1	2.90-7.30
PLR				0.170
< 217.91	74	9.0	6.36-11.64
≥ 217.91	25	6.8	5.50-8.10
PNI				< 0.001	2.715	1.476-4.994	0.001
< 45.6	54	5.1	2.87-7.33
≥ 45.6	45	10.4	9.20-11.60
HDL (mmol/L)				0.061
< 1.135	55	6.8	4.19-9.41
≥ 1.135	44	9.3	6.21-12.39
LDL (mmol/L)				0.616
< 2.26	52	8.3	3.93-12.67
≥ 2.26	47	8.2	5.94-10.46
TC (mmol/L)				0.546
< 4.045	56	6.8	2.75-10.85
≥ 4.045	43	9.0	7.13-10.87
TG (mmol/L)				< 0.001	0.138	0.066-0.288	< 0.001
< 1.315	55	11.5	7.36-15.64
≥ 1.315	44	3.3	2.00-4.60
With radiotherapy				0.012	0.777	0.418-1.446	0.426
Yes	24	11.0	6.37-15.63
No	75	6.8	4.88-8.72
With chemotherapy				0.070
Yes	79	9.0	7.16-10.84
No	20	2.6	0.00-5.45

ECOG PS: Eastern Cooperative Oncology Group performance status; HBV: Hepatitis B virus; CA199: Carbohydrate antigen 199; SII: Systemic immune-inflammation; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; PNI: Prognostic nutritional index; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; TC: Total cholesterol; TG: Triglyceride; OS: Overall survival.