Application value of multiphase contrast-enhanced computed tomography radiomics in preoperative evaluation of peritoneal metastasis in gastric cancer

Table 1 Comparison of basic characteristics of gastric cancer patients

Characteristic	Total (n = 200)	No peritoneal metastasis (n = 128)	Peritoneal metastasis (n = 72)	Statistical value	P value
Age (years)	63 (55, 71)	61 (53, 69)	66 (58, 74)	Z = -2.162	0.031
Gender				χ2 = 0.892	0.345
Male	134 (67.0)	89 (69.5)	45 (62.5)
Female	66 (33.0)	39 (30.5)	27 (37.5)
BMI (kg/m2)	22.8 (20.5, 25.2)	23.1 (20.8, 25.4)	22.3 (19.9, 24.8)	Z = -1.423	0.155
Clinical symptoms
Abdominal pain	156 (78.0)	97 (75.8)	59 (81.9)	χ2 = 1.098	0.295
Abdominal distension	89 (44.5)	52 (40.6)	37 (51.4)	χ2 = 2.284	0.131
Weight loss	124 (62.0)	74 (57.8)	50 (69.4)	χ2 = 2.745	0.098
Anemia	98 (49.0)	58 (45.3)	40 (55.6)	χ2 = 2.070	0.150
Blood routine indicators
Hemoglobin (g/L)	118 (102, 135)	124 (108, 142)	108 (94, 126)	Z = -2.648	0.008
White blood cell count (× 109/L)	6.8 (5.2, 8.9)	6.3 (4.9, 8.1)	7.6 (5.8, 9.8)	Z = -2.035	0.042
Platelet count (× 109/L)	285 (218, 356)	268 (205, 338)	312 (248, 389)	Z = -2.314	0.021
Liver and kidney function indicators
ALT (U/L)	28 (18, 45)	24 (16, 38)	35 (22, 58)	Z = -2.187	0.029
AST (U/L)	32 (21, 48)	28 (19, 42)	38 (26, 61)	Z = -2.458	0.014
Total bilirubin (μmol/L)	18.6 (12.4, 26.8)	16.2 (11.8, 23.4)	22.8 (15.7, 32.1)	Z = -2.319	0.020
Creatinine (μmol/L)	78 (65, 94)	74 (62, 89)	85 (71, 102)	Z = -2.108	0.035
Blood urea nitrogen (mmol/L)	5.8 (4.2, 7.6)	5.4 (4.0, 7.1)	6.5 (4.8, 8.9)	Z = -1.892	0.058
Laboratory indicators
CEA (ng/mL)	8.5 (3.2, 22.1)	5.8 (2.6, 14.3)	18.9 (8.7, 45.2)	Z = -5.834	< 0.001
CA19-9 (U/mL)	45.2 (18.7, 126.8)	28.4 (15.2, 78.6)	89.7 (42.3, 234.1)	Z = -4.921	< 0.001
CA72-4 (U/mL)	12.6 (4.8, 35.7)	7.9 (3.8, 21.4)	28.4 (12.1, 68.9)	Z = -5.127	< 0.001
Tumor differentiation degree				χ2 = 12.358	0.002
Well differentiated	23 (11.5)	20 (15.6)	3 (4.2)
Moderately differentiated	89 (44.5)	64 (50.0)	25 (34.7)
Poorly differentiated	88 (44.0)	44 (34.4)	44 (61.1)
Lauren classification				χ2 = 15.942	< 0.001
Intestinal type	78 (39.0)	61 (47.7)	17 (23.6)
Diffuse type	95 (47.5)	52 (40.6)	43 (59.7)
Mixed type	27 (13.5)	15 (11.7)	12 (16.7)
HER-2 expression				χ2 = 5.624	0.018
Negative	142 (71.0)	85 (66.4)	57 (79.2)
Positive	58 (29.0)	43 (33.6)	15 (20.8)

Data was showed as n (%) or median (Q1, Q3). BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; HER-2: Human epidermal growth factor receptor-2.