Clinical value of geriatric nutritional risk index and pan-immune-inflammation value in locally advanced gastric cancer receiving neoadjuvant chemotherapy

Table 4 Univariate and multivariate logistic regression analysis for pathological response of clinicopathologic characteristics in the cohorts, median (interquartile range)

Variables	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Gender
Male vs female	1.098 (0.507-2.376)	0.813
Age (years)	0.999 (0.965-1.034)	0.964
Smoking history
Yes vs no	0.764 (0.385-1.514)	0.440
Drinking history
Yes vs no	1.267 (0.636-2.522)	0.501
Diabetes
Yes vs no	1.672 (0.696-4.018)	0.250
Hypertension
Yes vs no	1.005 (0.477-2.117)	0.990
Location
1/3 lower	1 (reference)	NA
1/3 middle	1.28 (0.559-2.934)	0.559
1/3 upper	0.702 (0.174-2.836)	0.619
Total	0.468 (0.123-1.783)	0.266
Nutrition supplement
Yes vs no	1.788 (0.828-3.861)	0.139
Clinical T stage
T2	1 (reference)	NA	1 (reference)	NA
T3	0.662 (0.215-2.044)	0.473	1.071 (0.313-3.662)	0.913
T4	0.231 (0.072-0.747)	0.014	0.520 (0.132-2.051)	0.350
Clinical N stage
Positive vs negative	1.1 (0.498-2.429)	0.814
Clinical stage
Stage 3 vs stage 2	0.288 (0.141-0.589)	0.001	0.419 (0.178-0.986)	0.046
CEA, ng/mL	1 (0.907-1.102)	0.997
CA19-9, U/mL	0.997 (0.979-1.015)	0.714
hsCRP, mg/L	0.905 (0.795-1.03)	0.132
NRS2002 score
≥ 3 vs < 3	0.641 (0.296-1.392)	0.261
GNRI-PIV score
0	1 (reference)	NA	1 (reference)	NA
1	0.393 (0.181-0.856)	0.019	0.501 (0.221-1.137)	0.098
2	0.448 (0.113-1.776)	0.253	0.446 (0.104-1.909)	0.277

CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; hsCRP: High-sensitivity C-reactive protein; NRS2002: Nutritional Risk Screening 2002; GNRI: Geriatric nutritional risk index; PIV: Pan-immune-inflammation value; OR: Odds ratio; CI: Confidence interval; NA: Not available.