Clinical value of geriatric nutritional risk index and pan-immune-inflammation value in locally advanced gastric cancer receiving neoadjuvant chemotherapy

Table 3 Univariate and multivariate Cox regression analysis for disease-free survival of clinicopathologic characteristics in the cohorts, median (interquartile range)

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender
Male vs female	0.717 (0.414-1.24)	0.234
Age (years)	1.008 (0.983-1.035)	0.522
BMI (kg/m2)
Underweight	1 (reference)	NA
Normal	0.367 (0.112-1.207)	0.099
Overweight	0.312 (0.093-1.052)	0.060
Obese	0.322 (0.08-1.29)	0.110
Smoking history
No vs yes	0.758 (0.453-1.268)	0.291
Drinking history
No vs yes	0.642 (0.373-1.104)	0.109
Diabetes
Yes vs no	1.09 (0.551-2.156)	0.804
Hypertension
Yes vs no	1.174 (0.678-2.032)	0.567
Location
1/3 lower	1 (reference)	NA
1/3 middle	1.455 (0.785-2.697)	0.233
1/3 upper	1.056 (0.373-2.993)	0.918
Total	1.823 (0.838-3.967)	0.130
Nutrition supplement
No vs yes	1.097 (0.629-1.914)	0.743
Clinical T stage
T2	1 (reference)	NA
T3	0.586 (0.229-1.497)	0.264
T4	1.553 (0.654-3.686)	0.319
Clinical N stage
Positive vs negative	1.259 (0.679-2.335)	0.464
Clinical stage
Stage 3 vs stage 2	2.086 (1.143-3.809)	0.017	0.821 (0.394-1.71)	0.599
CEA, ng/mL	1.052 (0.985-1.123)	0.132
CA19-9, U/mL	1.010 (1.002-1.019)	0.018	1.005 (0.994-1.016)	0.374
hsCRP, mg/L	1.022 (0.968-1.08)	0.424
GNRI	0.955 (0.929-0.981)	0.001	0.962 (0.928-0.997)	0.035
PIV	1.002 (1.000-1.004)	0.040	1.001 (0.999-1.004)	0.209
NRS2002 score
≥ 3 vs < 3	1.904 (1.129-3.212)	0.016	0.872 (0.417-1.825)	0.717
Vascular invasion
Yes vs no	2.426 (1.448-4.064)	0.001	1.258 (0.699-2.264)	0.444
Perineural invasion
Yes vs no	2.148 (1.262-3.655)	0.005	0.977 (0.534-1.79)	0.941
Pathological T stage
T0	1 (reference)	NA	1 (reference)	NA
T1	4.619 (0.54-39.542)	0.162	5.224 (0.597-45.681)	0.135
T2	7.987 (1.038-61.429)	0.046	4.727 (0.583-38.327)	0.146
T3	13.694 (1.821-102.995)	0.011	3.158 (0.344-28.949)	0.309
T4	33.792 (4.55-250.976)	0.001	6.105 (0.655-56.896)	0.112
Pathological N stage
Positive vs negative	4.632 (2.685-7.992)	< 0.001	1.21 (0.544-2.691)	0.640
pathological stage
Stage 2-3 vs stage 1-0	6.459 (3.336-12.506)	< 0.001	4.257 (1.242-14.596)	0.021
Complication
Yes vs no	1.952 (1.165-3.272)	0.011	1.642 (0.92-2.93)	0.094

BMI: Body mass index; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; hsCRP: High-sensitivity C-reactive protein; GNRI: Geriatric nutritional risk index; PIV: Pan-immune-inflammation value; NRS2002: Nutritional Risk Screening 2002; HR: Hazard ratio; CI: Confidence interval; NA: Not available.