Clinical value of geriatric nutritional risk index and pan-immune-inflammation value in locally advanced gastric cancer receiving neoadjuvant chemotherapy

Table 2 Univariate and multivariate Cox regression analysis for overall survival of clinicopathologic characteristics in the cohorts, median (interquartile range)

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender
Male vs female	0.752 (0.436-1.295)	0.304
Age (years)	1.014 (0.989-1.041)	0.280
BMI (kg/m2)
Underweight	1 (reference)	NA
Normal	0.387 (0.118-1.266)	0.116
Overweight	0.308 (0.092-1.040)	0.058
Obese	0.316 (0.079-1.267)	0.104
Smoking history
No vs yes	0.693 (0.417-1.150)	0.156
Drinking history
No vs yes	0.564 (0.327-0.973)	0.039	0.504 (0.270-0.939)	0.031
Diabetes
Yes vs no	1.238 (0.643-2.385)	0.522
Hypertension
Yes vs no	1.293 (0.760-2.198)	0.343
Location
1/3 lower	1 (reference)	NA
1/3 middle	1.373 (0.746-2.528)	0.309
1/3 upper	1.011 (0.358-2.854)	0.984
Total	1.655 (0.764-3.584)	0.201
Nutrition supplement
Yes vs no	1.153 (0.664-2.003)	0.613
Clinical T stage
T2	1 (reference)	NA
T3	0.648 (0.257-1.633)	0.358
T4	1.533 (0.646-3.639)	0.333
Clinical N stage
Positive vs negative	1.166 (0.641-2.121)	0.615
Clinical stage
Stage 3 vs stage 2	1.836 (1.036-3.255)	0.038	0.868 (0.432-1.741)	0.690
CEA, ng/mL	1.048 (0.984-1.115)	0.145
CA19-9, U/mL	1.011 (1.002-1.019)	0.016	1.004 (0.992-1.015)	0.536
hsCRP, mg/L	1.022 (0.970-1.078)	0.407
GNRI	0.953 (0.927-0.980)	< 0.001	0.956 (0.923-0.991)	0.013
PIV	1.002 (1.000-1.004)	0.019	1.002 (1-1.005)	0.041
NRS2002 score
≥ 3 vs < 3	1.768 (1.055-2.964)	0.031	0.745 (0.358-1.55)	0.431
Vascular invasion
Yes vs no	2.096 (1.259-3.489)	0.004	1.32 (0.732-2.38)	0.356
Perineural invasion
Yes vs no	2.122 (1.253-3.593)	0.005	1.058 (0.568-1.968)	0.860
Pathological T stage
T0	1 (reference)	NA	1 (reference)	NA
T1	2.750 (0.555-13.626)	0.215	2.957 (0.575-15.202)	0.194
T2	3.871 (0.866-17.296)	0.076	2.061 (0.421-10.086)	0.372
T3	7.216 (1.673-31.133)	0.008	2.082 (0.353-12.265)	0.418
T4	15.956 (3.738-68.105)	< 0.001	2.888 (0.475-17.565)	0.250
Pathological N stage
Positive vs negative	3.849 (2.279-6.500)	< 0.001	1.154 (0.519-2.565)
pathological stage
Stage 2-3 vs stage 1-0	5.459 (2.941-10.132)	< 0.001	3.720 (1.061-13.044)	0.040
Complication
Yes vs no	1.823 (1.096-3.033)	0.021	1.450 (0.823-2.551)	0.198

BMI: Body mass index; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; hsCRP: High-sensitivity C-reactive protein; GNRI: Geriatric nutritional risk index; PIV: Pan-immune-inflammation value; NRS2002: Nutritional Risk Screening 2002; HR: Hazard ratio; CI: Confidence interval; NA: Not available.