Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients

doi:10.4251/wjgo.v18.i2.115224

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Feb 15, 2026; 18(2): 115224
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115224

Table 3 Comparison of clinical data of older patients with colorectal cancer in the high/Low modified frailty index and systemic immune-inflammation index groups, n (%)/mean ± SD

Variable	Pre-operative mFI		t/χ²	Pre-operative SII		t/χ²
Variable	Low group (n = 158)	High group (n = 89)	t/χ²	Low group (n = 177)	High group (n = 70)	t/χ²
Age (years)	70.84 ± 6.17	72.71 ± 6.90	2.193^a	71.27 ± 6.50	72.13 ± 6.48	0.941
Sex			0.173			0.142
Male	88 (55.70)	52 (58.43)		99 (55.93)	41 (58.57)
Female	70 (44.30)	37 (41.57)		78 (44.07)	29 (41.43)
BMI (kg/m²)	22.62 ± 1.28	22.74 ± 1.43	0.637	22.71 ± 1.32	22.56 ± 1.36	0.780
Smoking history			1.488			2.130
Yes	50 (31.65)	35 (39.33)		56 (31.64)	29 (41.43)
No	108 (68.35)	54 (60.67)		121 (68.36)	41 (58.57)
Drinking history			0.171			1.831
Yes	61 (38.61)	32 (35.96)		62 (35.03)	31 (44.29)
No	97 (61.39)	57 (64.04)		115 (64.97)	39 (55.71)
Operation time (minutes)	163.11 ± 20.68	169.03 ± 23.21	2.068^a	162.72 ± 21.33	171.63 ± 21.69	2.944^a
Preoperative bleeding (mL)	123.35 ± 26.60	123.58 ± 28.53	0.064	122.90 ± 27.78	124.79 ± 26.01	0.488
Tumor site			1.909			2.103
Rectum	89 (56.33)	42 (47.19)		99 (55.93)	32 (45.71)
Colon	69 (43.67)	47 (52.81)		78 (44.07)	38 (54.29)
Tumor size			9.573^a			0.178
< 5 cm	103 (65.19)	40 (44.94)		101 (57.06)	42 (60.00)
≥ 5 cm	55 (34.81)	49 (55.06)		76 (42.94)	28 (40.00)
Degree of tumor differentiation			4.688			0.129
High	70 (44.30)	46 (51.69)		82 (46.33)	34 (48.57)
Moderate	69 (43.67)	27 (30.34)		70 (39.55)	26 (37.14)
Poor	19 (12.03)	16 (17.98)		25 (14.12)	10 (14.29)
TNM stage			0.094			1.731
I	51 (32.28)	29 (32.58)		55 (31.07)	25 (35.71)
II	79 (50.00)	43 (48.31)		92 (51.98)	30 (42.86)
III	28 (17.72)	17 (19.10)		30 (16.95)	15 (21.43)

^aP < 0.05.

mFI: Modified frailty index; SII: Systemic immune-inflammation index; TNM: Tumor-node-metastasis; BMI: Body mass index.

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Citation: Qi XS, Xie J, Liu NL, Yang L. Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients. World J Gastrointest Oncol 2026; 18(2): 115224
URL: https://www.wjgnet.com/1948-5204/full/v18/i2/115224.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i2.115224

Qi XS, Xie J, Liu NL, Yang L. Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients. World J Gastrointest Oncol 2026; 18(2): 115224 [PMID: 41695912 DOI: 10.4251/wjgo.v18.i2.115224]

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