Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a-/- mice

doi:10.4251/wjgo.v18.i2.114161

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Feb 15, 2026; 18(2): 114161
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.114161

Table 1 Summary of molecular marker expression changes in the Atp4a^-/- mouse model after taurine intervention

Marker	Type	Function	WT expression	Model expression vs WT	Taurine intervention expression vs model	P value (taurine vs model)	Detection method
CDX2	Intestinal transcription factor	Regulates intestinal metaplasia initiation	Baseline	Upregulated (significant)	Downregulated (significant)	< 0.05 (mRNA), < 0.0001 (protein)	qPCR, IHC
MUC2	Intestinal mucin	Goblet cell product in intestinal epithelium	Baseline	Upregulated (significant)	Downregulated (significant)	< 0.05 (mRNA), < 0.01 (protein)	qPCR, IHC
TFF3	Intestinal repair factor	Associated with GIM severity	Baseline	Upregulated (significant)	Downregulated (significant)	< 0.05 (mRNA), < 0.01 (protein)	qPCR, IHC
MUC5AC	Gastric mucin	Surface mucous cell product	Baseline	Downregulated (nonsignificant at mRNA)	Upregulated (significant)	< 0.05 (mRNA), < 0.001 (protein)	qPCR, IHC

CDX2: Caudal type homeobox 2; GIM: Gastric intestinal metaplasia; IHC: Immunohistochemistry; MUC2: Mucin 2; MUC5AC: Mucin 5AC; qPCR: Quantitative PCR; TFF3: Trefoil factor family 3; WT: Wild-type.

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Citation: Liu K, Zhang X, Li FZ, Zheng PY, Mi Y. Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a^-/- mice. World J Gastrointest Oncol 2026; 18(2): 114161
URL: https://www.wjgnet.com/1948-5204/full/v18/i2/114161.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i2.114161

Liu K, Zhang X, Li FZ, Zheng PY, Mi Y. Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a^-/- mice. World J Gastrointest Oncol 2026; 18(2): 114161 [PMID: 41695925 DOI: 10.4251/wjgo.v18.i2.114161]

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