Endoscopic treatment of calcifying fibrous tumor of the esophagus combined with esophageal cancer: A case report

Figure 3 Histopathological and immunohistochemical features of the esophageal calcifying fibrous tumor and squamous cell carcinoma. A: High-power hematoxylin and eosin (HE) staining (× 100) showing multiple basophilic calcified deposits within dense collagenous stroma. Scale bar = 100 μm; B: Immunohistochemical staining for Ki-67 (× 100) showing a low proliferation index (< 1%), consistent with a benign lesion. Scale bar = 100 μm; C: Low-power HE staining (× 100) showing paucicellular dense collagenous tissue with scattered bland spindle cells, without significant cytologic atypia or increased mitotic activity. Scale bar = 100 μm; D: High-power HE staining (× 100) showing chondroid-like hyalinized stroma with focal calcification. Scale bar = 100 μm; E: HE staining (× 40) of the mucosal lesion showing moderately differentiated esophageal squamous cell carcinoma invading the submucosa. Scale bar = 200 μm.