Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling

Figure 9 Impact of virtual fatty acid desaturase 1 knockout on the gene regulatory network in monocytes/macrophages. A: Scatter plot showing the distribution of differentially expressed genes following fatty acid desaturase 1 knockout. The X-axis represents the Z score (differential regulation score), and the Y-axis represents the negative logarithm of the adjusted P value. Positive Z scores indicate upregulated regulatory activity after knockout (positive regulation), whereas negative values indicate downregulation. The dashed line indicates the significance threshold (adjusted P value < 0.05); B: Bar plot displaying the top 20 genes most significantly affected by fatty acid desaturase 1 knockout along with their corresponding Z scores. FADS: Fatty acid desaturase.