Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling

doi:10.4251/wjgo.124110

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124110
Published online Nov 15, 2026. doi: 10.4251/wjgo.124110

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Figure 5 Fatty acid desaturase 1 knockdown attenuates lipid peroxidation in M1 macrophages. M1 macrophages were transfected with siRNA negative control or si-fatty acid desaturase 1 for 48 hours, and lipid peroxidation was assessed using BODIPY™ 581/591 C11 staining. Representative fluorescence images show reduced green fluorescence (oxidized C11-BODIPY) and increased red fluorescence (reduced C11-BODIPY) in si-fatty acid desaturase 1-treated cells compared with those in siRNA negative controls, indicating decreased lipid peroxidation. FADS: Fatty acid desaturase; NC: Negative control.

Citation: Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/124110.htm
DOI: https://dx.doi.org/10.4251/wjgo.124110

Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110 [DOI: 10.4251/wjgo.124110]

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