Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling

Figure 1 Expression levels of 5 genes in esophageal cancer tissues. A: The expression level of fatty acid desaturase 1 in esophageal cancer tissues was significantly greater than that in normal esophageal tissue; B: The expression level of fatty acid desaturase 2 in esophageal cancer tissues was significantly greater than that in normal tissues; C: The expression level of elongation of very long chain fatty acids protein 5 in esophageal cancer tissues was significantly greater than that in normal tissues; D: The expression level of SRC proto-oncogene in esophageal cancer tissues was significantly greater than that in normal tissues; E: No significant difference in peroxisome proliferator-activated receptor gamma expression was detected between esophageal cancer and normal tissues. ^aP < 0.05, ^cP < 0.0001, NS: Not significant (P ≥ 0.05). FADS1: Fatty acid desaturase 1; FADS2: Fatty acid desaturase 2; ELOVL5: Elongation of very long chain fatty acids protein 5; SRC: SRC proto-oncogene (sarcoma gene); PPARG: Peroxisome proliferator-activated receptor gamma.