Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling

doi:10.4251/wjgo.124110

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124110
Published online Nov 15, 2026. doi: 10.4251/wjgo.124110

Table 3 Molecular docking results of the candidate compound BRD-K95779464 with the fatty acid desaturase 1protein

CurPocket ID	Vina score	Cavity volume (Å³)	Center (X, Y, Z)	Docking size (X, Y, Z)
C1	-8.3	5051	(-4, 8, -1)	(28, 28, 35)
C5	-8.1	163	(-8, -12, 13)	(22, 22, 22)
C2	-7.6	358	(-2, -5, -16)	(22, 22, 22)
C3	-6.2	203	(14, 13, 9)	(22, 22, 22)
C4	-5.7	186	(7, 8, -23)	(22, 22, 22)

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Citation: Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110
URL: https://www.wjgnet.com/1948-5204/full/v18/i11/124110.htm
DOI: https://dx.doi.org/10.4251/wjgo.124110

Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110 [DOI: 10.4251/wjgo.124110]

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